PHARMACOLOGICAL VALIDATION OF GUDUCHI (TINOSPORACORDIFOLIA): A REVIEW OF RECENT RESEARCH”-COVERING MODERN STUDIES ON ITS IMMUNO MODULATORY, ANTI-INFLAMMATORY, AND ADAPTOGENIC EFFECTS

*Dr. Tarun Suryakant Paliwal and Dr. Parshuram Sahadu Pawar

Recent global health challenges have increased public awareness of the need to enhance immunity and overall well-being. Alongside a nutritious diet and regular exercise, there is growing interest in natural plant-based therapies that support immune health. In Ayurvedic medicine, Tinospora cordifolia (Guduchi), a deciduous climbing shrub native to India, is renowned for its multifaceted therapeutic potential. Traditionally used to treat both acute and chronic inflammatory conditions, Guduchi also plays a key role in strengthening immune function and promoting systemic balance. Guduchi is considered an effective immunomodulator, capable of regulating immune responses rather than merely stimulating or suppressing them. It also possesses potent anti-inflammatory properties, helping to reduce inflammatory mediators and oxidative stress—key contributors to chronic diseases. Additionally, Guduchi is recognized as a natural adaptogen, enhancing the body's ability to adapt to physical and emotional stress by maintaining homeostasis. Typically administered as a decoction or as part of polyherbal formulations, Guduchi has been extensively studied. Over 200 bioactive compounds have been identified from its aqueous and alcoholic extracts, with clerodane-type diterpenoids being the most prominent. Research indicates its ability to modulate crucial signaling pathways related to inflammation, cell proliferation, and immune function. While further studies are needed to isolate and characterize its active components, existing evidence strongly supports Guduchi’s role as a safe and effective immunomodulatory, anti-inflammatory, and adaptogenic agent.