IN-VIVO EVALUATION OF HYPOLIPIDEMIC POTENTIAL OF ETHANOLIC EXTRACT OF PYRUS PYRIFOLIA FRUIT PEEL
Deepak Gowda N. S.*, Dr. Suresha B. S., Dr. T. Balasubramanian, Ahalya Devi K. H., Apoorva B. H. and Kuldeep M. G.
The present study was designed to evaluate the in-vivo hypolipidemic potential of the ethanolic extract of Pyrus pyrifolia fruit peel (EEPP) using high-fat diet-induced hyperlipidemic Wistar albino rats. Hyperlipidemia was induced by administering a mixture of vanaspati ghee and coconut oil (3:1, v/v) at a dose of 3 mL/kg body weight for 21 days, followed by treatment with the extract for another 21 days. The animals were divided into five groups-normal control, hyperlipidemic control, standard drug (atorvastatin 10 mg/kg), low-dose EEPP (200 mg/kg), and high-dose EEPP (400 mg/kg). Biochemical parameters including triglycerides (TG), total cholesterol (TC), HDL-C, LDL, VLDL and atherogenic index (AI) were estimated using standard diagnostic kits. The hyperlipidemic control group showed a significant rise in TG, TC, LDL and VLDL levels with a marked reduction in HDL-C. Treatment with EEPP significantly and dose-dependently restored lipid parameters toward normal levels. The high-dose extract exhibited a greater hypolipidemic effect, comparable to the standard atorvastatin-treated group. Additionally, a marked decrease in AI was observed, suggesting reduced atherogenic risk. These findings confirm that Pyrus pyrifolia fruit peel possesses potent lipid-lowering and cardioprotective properties, likely attributed to its flavonoids and phenolic constituents with antioxidant potential. Thus, EEPP may serve as a promising natural therapeutic agent for the management of hyperlipidemia and prevention of cardiovascular disorders.
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