INVESTIGATING THE LIPID-LOWERING POTENTIAL OF LITCHI CHINENSIS SEED EXTRACT THROUGH IN-VIVO STUDIES
Kavya M. K.*, Dr. Suresha B. S., Dr. T. Balasubramanian, Ahalya Devi K. H., Preethi B. H. and Puneeth Kumar S. L.
The present study investigates the lipid-lowering potential of Litchi chinensis seed extract through in-vivo evaluation in hyperlipidemic animal models. Hyperlipidemia was induced to assess alterations in biochemical parameters, including triglycerides (TG), total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL), very low-density lipoprotein (VLDL), and the atherogenic index (AI). The hypercholesterolemic (HC) group showed significant elevation in TG, TC, LDL, VLDL, and AI levels, accompanied by a marked reduction in HDL compared to the normal control group, confirming successful induction of hyperlipidemia. Administration of Litchi chinensis seed extract at two different doses resulted in significant restoration of lipid parameters toward normal values. The high-dose group exhibited a more pronounced reduction in TG, TC, LDL, VLDL, and AI, along with an increase in HDL, comparable to the standard drug-treated group. The low-dose treatment also demonstrated a moderate but statistically significant improvement. These findings indicate that the hypolipidemic activity of Litchi chinensis seed extract may be attributed to its rich content of bioactive phytoconstituents such as flavonoids, polyphenols, and saponins, which are known to modulate lipid metabolism and enhance antioxidant defense. Overall, the study concludes that Litchi chinensis seed extract exhibits potent lipid-lowering, supporting its potential use as a natural therapeutic agent for the management of hyperlipidemia.
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