INTEGRATED PERSPECTIVES ON BRAIN-TARGETED DRUG DELIVERY: BARRIERS, RECEPTORS, PERMEABILITY DETERMINANTS, AND ASSESSMENT METHODS
A. Veenadevi*, S. Aswini, M. Padma Sai Sree, S.S.N.K. Tejaswi, B. Vanitha, B. Divya Sri
Achieving effective drug transport to the brain is one of the relevance of contemporary pharmaceutical sciences, given the rising incidence of neurological and brain disorders associated with the aging population. However, because of the presence of these barriers the blood-brain barrier (BBB), the blood-brain tumor barrier (BBTB), efflux pumps, and the blood cerebrospinal fluid barrier (BCSFB) which regulate the path of circulating drug molecules into the brain, brain delivery of a drug is a complex task for treating CNS diseases such as neurodegenerative disorders (Parkinson's, Alzheimer's disease), schizophrenia, stroke, epilepsy, brain tumor, migraine, dementia, and meningitis. For the treatment of many CNS illnesses, general techniques that can improve drug transport to the brain are very desirable. Reducing toxicity and improving treatment effectiveness can be achieved by localizing medications at the intended site of action. The following topics will be covered in detail in this review: receptor-mediated drug delivery, brain permeation parameters and their evaluation methods, obstacles in the brain targeted drug delivery system, the mechanism of drug transfer via BBB, issues encountered in the brain targeted drug delivery system, and its applications in the treatment of various CNS diseases.
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