ASSESSMENT OF SERUM BİSPHENOL-A CONCENTRATİONS AND PROTEİNURİA LEVELS İN PATİENTS WİTH PROTEİNURİA

Dr. Cem Kaya, Dr. Serdar Kahvecioğlu, Dr. Esra Öztürk Kaya, Dr. Ali Erol*

Objective: Bisphenol A (BPA) is a primary raw chemical utilized predominantly in the manufacturing of plastics. BPA exhibits inflammatory and nephrotoxic effects on the organism. This study examined the correlation between serum BPA and proteinuria. Methods: A total of 40 patients with stage 1 and 2 chronic kidney disease (CKD) and proteinuria, devoid of structural renal abnormalities, who came to a tertiary healthcare center from October 2019 to October 2020, were included, along with a control group of 35 patients. Results: Upon examination of the data between the two groups, the median age of the patient group was found to be 39 years (range 19-65), whereas the median age of the control group was 32 years (range 24-58). The groups exhibit no disparity for gender and age. (with p=0.8 and p=0.6, respectively). The GFR level was 92.09±22.35 in the proteinuric cohort and 105.74±10.2 in the control cohort. The creatinine concentration was 0.90±0.26 mg/dl in the proteinuric cohort and 0.79±0.15 mg/dl in the control cohort. The PRCR levels were 1382 mg/g (range 123-4338) in the proteinuric group and 87 mg/g (range 38-307) in the control group. Substantial disparities were seen among the groups (p=0.001, p=0.048, and p=0.001, respectively). BPA concentrations were measured at 1.38 ng/ml (0.51-14.50) in the proteinuric group and 4.93 ng/ml (0.56-14.50) in the control group (p=0.08). Conclusion: Serum BPA concentrations were correlated with GFR levels. Concerns have been expressed regarding the potential for BPA exposure to induce clinically significant alterations in kidney function, linked to exposure to prevalent environmental contaminants at existing levels.