EFFECT OF NON-POLAR FRACTION OF CINNAMOMUM TAMALA LEAVES ON INTESTINAL α-GLYCOSIDASE ENZYME IN NORMAL AND DIABETIC RATS
*Dr. Jitendra Kumar Chaurasia
Cinnamomum tamala (CT) is a member of the Lauraceae family and its leaves were used as food spices for flavor. The leaves are also used as an antidiabetic agent, and many more in the Indian Medicine System. This potential of CT leaves towards postprandial hyperglycemia is not known, so it is planned here for the same. Here, we have prepared hexane fraction of CT leaves (CTH, most active) and shown their effect on oral, glucose and sucrose tolerance and α- glycosidase activity for postprandial hyperglycemia. CTH @ 400 and 800 mg/kg body weight were given to normal and diabetic rats and blood glucose was monitored for 2 hrs. For the study of the mechanism, their effect was measured on alpha glycosidase activity and its effect on postprandial hyperglycemia. Results suggested that CTH reduced postprandial hyperglycemia by inhibiting Alpha glycosidase activity. Acarbose which is a well-known alpha glycosidase inhibitor, is used as a reference drug for postprandial hyperglycemia.
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