FAST ORAL DISSOLVING FILMS REVIEW
*Alhaji Kolo Shettima, Alhaji Saleh Isyaku, Yamlikha Maina, Umar Mohammad, Abdulrahman Alimi Kufti, Ahmad Lawan Abba, Mohammed Maina Jawa
Fast oral dissolving films represent an advanced oral solid dosage form, offering flexibility and user comfort. These films rapidly disintegrate and dissolve within one minute when placed in the mouth, without the need for water or chewing. This dosage form enables medication to bypass first-pass metabolism, potentially enhancing bioavailability. Mouth dissolving films may improve onset of action, reduce required dosing, and mitigate the risk of choking. Their formulation incorporates both visual and performance characteristics, utilizing plasticized hydrocolloids and active pharmaceutical ingredient (API) taste-masking agents, which are laminated by solvent casting or semisolid casting methods. The solvent casting method is preferred due to its ability to produce films with uniform thickness, a glossy appearance, and superior physical properties. Evaluation of mouth dissolving films includes assessment of parameters such as thickness, folding endurance, disintegration time, and dissolution time.
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