A specific, accurate, precise, linear and cost effective HPLC method was developed for estimation of Linagliptin. Separation of the Linagliptin was achieved on a Column C18 (250 mm x 4.6 mm, 5 µm) Xterra @ RP 18 is suitable, using a mobile phase consisting of a mixture of 50 volumes of buffer solution and 50 volumes of methanol (v/v). The flow rate was 1mL/min and detection wavelength was 293 nm. The linearity was found in the concentration of 0.0075, 0.0125, 0.0200, 0.0250, 0.0375, mg/mL with a correlation coefficient (R2) of 0.999. The retention time of Linagliptin was 5.58 minutes. The predicted method was validated as per the International Conference for Harmonization guidelines for the parameters: Linearity, Accuracy, Robustness, Precision, Specificity etc. This method can be used for routine analysis of quality control of Linagliptin in tablet dosage form.

AI in healthcare, especially in cancer management, enhances diagnostic accuracy, treatment personalization, and patient outcomes. Machine learning and deep learning algorithms assist in early detection, precise treatment planning, and prognosis prediction. AI’s ability to analyze complex medical data quickly and accurately drives innovations in precision medicine and early intervention, ultimately improving survival rates and patient care. Currently, AI in cancer care is gaining momentum globally, particularly in developed countries like the U.S., the UK, and China. AI-driven tools are used for early detection via imaging, precision diagnosis, personalized treatment plans, and predicting patient prognosis. Major advancements have been made in integrating AI in clinical workflows, although challenges remain in data accessibility, regulation, and model transparency. In India, AI is increasingly being adopted in cancer care, with advancements in early detection through imaging and biomarker analysis. AI-driven tools aid in accurate diagnosis, personalized treatment plans, and prognosis prediction. While major institutions and startups are pioneering AI applications in oncology, challenges like data quality, infrastructure, and regulatory frameworks remain, limiting widespread adoption. The objective of this paper is to review the current applications of AI in cancer management, focusing on early detection, diagnosis, treatment, and prognosis. It aims to analyze the key challenges hindering broader adoption, such as data quality, ethical concerns, and regulatory issues. Furthermore, the paper explores future research opportunities, including advancements in AI technologies, integration with clinical practices, and their potential to revolutionize personalized cancer care and improve patient outcomes.

Mango ginger (Curcuma amada), an annual plant from the Zingiberaceae family, is notable for its unique mango-flavored rhizomes and significant medicinal value. Traditionally used in culinary applications, particularly in pickles, it also holds a prominent place in Ayurvedic and Unani medicine as an appetizer, antipyretic, aphrodisiac, diuretic, and treatment for various ailments such as skin diseases, bronchitis, asthma, and inflammation. The rhizomes exhibit a wide range of biological activities, including antioxidant, antibacterial, antifungal, anti-inflammatory, cytotoxic, and analgesic effects. Chemically, C. amada is rich in starch, phenolic acids, curcuminoids, and volatile oils, with key terpenoids like difurocumenonol, amadannulen, and amadaldehyde. GC/MS analysis revealed essential oil components such as α-pinene, p-cymene, camphor, and β-curcumene. Essential oils extracted through various methods—hydrodistillation, steam distillation, microwave-assisted extraction, and ultrasound-assisted extraction—demonstrated notable antibacterial, anti-inflammatory, larvicidal, and insecticidal properties, with UAE and MAE showing enhanced antibacterial efficacy.

Solid dispersions (SDs) of atorvastatin (ATS) using PEO-PPO block copolymer resulted in the formation of an amorphous product with enhanced dissolution and bioavailability. Solubility enhancement was observed in the presence of selected carriers and it increased with the increase in concentration of carriers. The carrier and the active ingredient are dissolved in a suitable organic solvent is evaporated to an elevated temperature or under vaccum. As the solvent is being removed, super saturation occurs followed by simultaneous precipitation of the constituents resulting in a solid residue. The solvent-based process uses organic solvent to dissolve and intimately disperse the drug and carrier molecule The accumulative solubility of atorvastatin (ATS) from PEO- PPO block copolymer (Poloxamer 188) was found to be superior from glyceryl monostearate and PEG 4000 carriers due to increased content which played major role in solubility enhancement thus improving dissolution rate of SD2 batch with maximum drug release (98.08 %) in 120 minutes. The optimized SDs were characterized by saturation solubility study, drug content, in vitro dissolution, fourier transform infra-red spectroscopy, scanning electron microscopy, and x-ray diffraction. Capsules containing optimized SDs were prepared and compared with marketed brand (LIPITOR®). Finally it can be concluded that optimized SDs of ATS ameliorate the solubility and dissolution of drug. Since the batch SD2 elicited superior results, it can be proposed as good candidate for systemic product development.

Sharir Rachana is an integrative branch of Ayurveda that studies the human body in its most minute form to an organized structural form. Sushruta, first carried out a detailed cadaveric study of the human body around 2000 yrs ago and laid the bedrock of Sharir Rachana Vigyan in his Samhita. Cadaveric studies thus helped the ancient seers explore many structures of human body and thus with the passing time this scientific branch evolved with a complex nomenclature of the various body parts. These nomenclatures and definitions of the basic bodily structures are compiled under the heading of Paribhasha Sharir. The knowledge of Paribhasha Sharir holds utmost importance in the field of surgery and medicine as well. However lack of social and technological advancements in the era when Ayurveda was encrypted by the Sages, there emerged out various controversies over a particular structure. Acharyas have stated out individual opinions over a single structure that created a big confusion to the forth coming generations. With developments in recent times these confusions were gradually resolved keeping the original texts and definitions unaltered. Thus the present article is a framework that reviews the controversies and applied aspects of Paribhasha Sharir in Rachana Sharir Vigyan.

Cancer treatment with conventional chemotherapy drugs often faces challenges such as poor solubility, rapid metabolism, systemic toxicity, and non-specific distribution. Melphalan, an alkylating agent widely used in multiple myeloma and other cancers, is clinically effective but suffers from reduced stability and limited bioavailability. To address these drawbacks, the present work focused on developing melphalan-loaded niosomes as a novel nanocarrier system. The formulations were prepared using the thin film hydration technique with cholesterol and non-ionic surfactants. They were further analyzed for particle size, surface charge, drug entrapment efficiency, pH stability, compatibility studies, and in vitro release behavior. The optimized niosomal formulation exhibited nanoscale vesicles with uniform distribution, high entrapment efficiency, and stable zeta potential. FTIR analysis confirmed no significant drug–excipient interactions. The release profile demonstrated sustained drug release over an extended period, with kinetics indicating a diffusion-controlled mechanism. The findings suggest that melphalan-loaded niosomes can enhance drug stability, provide controlled delivery, reduce systemic side effects, and thereby improve therapeutic efficacy in cancer management.

Through this review, we are trying to explore the relevant work done on the OM MANTRA CHANTING EFFECT On the Mental health and its benefits. Mantra yoga is one a part of yoga since ancient times. The Upnishads are full of references regarding the “OM” Mantra. OM is the matrix of all mantras. By doing its chanting which neutralize Raja (Agitation) and the Tama (Inertia) and calms the mind, brings focus and is great for controlling breath and stress levels. Now a days the most common problem in life is stress and anxiety. “OM CHANTING” is a simple practice, it needs less time as well as doesn‟t require expert or trainer while performing. Definitely by practice we can prevent psychosomatic disorders manage anger, stress and anxiety and it makes the person healthy and well-being.

Amoung children worldwide diarrheal disease particularly acute gastroentritis, still remain leading cause of morbidity and mortality, even though a substantial portion of decrease in mortality has been achieved which is attributable to worldwide campaigns to treat acute diarrhea with oral rehydration therapy (ORT), which today includes rehydration and maintenance fluids apart from oral rehydration solutions (ORS) combined with continued age appropriate nutrition. Although substantial in vitro and in vivo data support the role of continued nutrition in improving gastro intestinal function and anthropometric, biochemical and clinical outcome early appropriate feeding is often withheld.

Aim of study: Karsya is very common disease in children of age group 6months to 5 years.In ayurveda Karshya is described as Apatarpanajanya vyadhi & Due to Rasavaha Shrotodusti wherevata dosha plays a very important role in the pathogenesis, along with that vitiated Pitta. Aim of article is to review antimicrobial activity against various organisms and nutritional value of drug. Material and methods: Literary review was conducted with help of several important Ayurvedic and Modern text books, Research papers, Journals to collect information on Amritpraasha Ghrita. The description of Karsya clearly correlates with under nutrition. Karshya is described in almost all samhita from both point of view i.e. preventiveas well as curative. Result: Amritpraasha Ghrita orally is effective in improving anthropometrical measurements like weight, mid arm circumference, Chest circumference and body mass index and in improving the associated complaints of Karshya like Kshudha and appearance. Interpretation & Conclusion: Karshya can be coherently and efficaciously managed using Amritapraasha ghrita and thus prevent further complications.

Ophthalmia Neonatorum is one of the diseases of neonates. In Ayurveda Kukunaka vyadhi was explained in samhita has similar features like Ophthalmia Neonatorum, so Kukunaka can be related to Ophthalmia Neonatorum. It is the conjunctivitis of newborns occurring during first month of life. It may be infectious or noninfections. It causes pain and tenderness in eyeball, purulent, mucoid / mucopurulant discharge, hyperaemia, photophobia and blindness, if left untreared. Hence, I decided to address Kukunaka (Ophthalmia Neonatorum) as it may lead to blindness, if left untreated.

Down Syndrome is most common chromosomal abnormality. Incidence 1:700-800 live births. According to Ayurveda Down Syndrome occurs due to Vata Dosh predominance and also due to Beej, Beejabhaga dosha and Bheejbhaga avayava abnormality. Down Syndrome is Found in newborn with clinical features like poor moro reflex and in children with Hypotonia, Mental Retardation. Treatments are useful in Down Syndrome cases in Shiropichu with Dhanwantar taila, Abhanga with Dhanwantar tail, Panda Sweda etc, and physiotherapy is also benifical for Down Syndrome.

Aim of study: Karsya is very common disease in children of age group 6months to 5 years.In ayurveda Karshya is described as Apatarpanajanya vyadhi & Due to Rasavaha Shrotodusti wherevata dosha plays a very important role in the pathogenesis, along with that vitiated Pitta. Aim of article is to review antimicrobial activity against various organisms and nutritional value of drug. Material and Methods: Literary review was conducted with help of several important Ayurvedic and Modern text books, Research papers, Journals to collect information on Amritpraasha Ghrita. The description of Karsya clearly correlates with under nutrition. Karshya is described in almost all samhita from both point of view i.e. preventiveas well as curative. Result: Amritpraasha Ghrita orally is effective in improving anthropometrical measurements like weight, mid arm circumference, Chest circumference and body mass index and in improving the associated complaints of Karshya like Kshudha and appearance. Interpretation & Conclusion: Karshya can be coherently and efficaciously managed using Amritapraasha ghrita and thus prevent further complications.

Shayyamutra (Primary Nocturnal Enuresis) is a common problem for small age groups and also of older age group too. When young children are in trouble it become a nuisance for them as well as parents. Moreover, it hampers the emotional and social growth of the child. In the management of conditions like enuresis the other system of medicines have their own limitations. Though claims for cure rate are very great by contemporary science but associated hazards also have been noticed. Hazards due to drugs compel the medical fraternity to search a cure that would be better and convenient for enuretic child in all aspects. Ayurveda is the only medical system in the world that clearly emphasizes the treatment of ailments and further maintenance of health by reversing the pathology. Thus, this problem was selected for the present review study. A genuine effort will be made to understand the psychological state of the patients and guide them appropriately.

The free radicals are formed because of improper metabolism results production of the toxins in the body because of that may produce different condition which may be thought of Amavisha (Free radicals). Ultimately may lead to destruction of cell and weakened body tissues. To overcome of this Different Rasayana (rejuvenation therapy) may help in dissolving free radicals and boost up the cells and body tissue. This Article enlightens the concept of Rasayana, Importance, Kayakalpa (renewal of body), Benefits, Rasayana based on Age, Rasayana according to disease, Active constituents present in Rasayana and Immunomodulators etc.

Background: Computed Tomography Urography (CTU) is a non-invasive imaging modality increasingly utilized for detailed evaluation of the urinary tract and kidneys. Its ability to provide high-resolution images makes it instrumental in diagnosing a variety of renal pathologies. Objective: This study aims to explore the diagnostic role and effectiveness of CT urography in assessing renal diseases such as tumors, calculi, obstructions, congenital anomalies, and infections. Methodology: A qualitative review of 40 published articles was conducted using databases like PubMed and Scopus. Selection was based on inclusion criteria involving cases of renal disease assessed using CT urography. Clinical parameters such as age, sex, symptom onset, and history were considered for analysis. Results: The study confirms CT urography's clinical utility in diagnosing renal masses, stones, obstructive uropathy, infections, and anatomical anomalies. CTU provides critical details regarding lesion morphology, extent of obstruction, and presence of complications like hydronephrosis. However, its use involves exposure to ionizing radiation, necessitating judicious application, especially in vulnerable populations. Conclusion: CT urography is a valuable, detailed imaging technique for assessing renal pathology, guiding diagnosis, and influencing treatment strategies. While it offers superior anatomical insights, its radiation exposure risk mandates selective and cautious usage, often in combination with other diagnostic modalities.